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KMID : 0882419940470030313
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Korean Journal of Medicine
1994 Volume.47 No. 3 p.313 ~ p.318
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Clinical Usefulness of the Antimicrosomal Antibody in the Postpartum Period
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성현주
임인기/천진옥/임성희/최문기/유형준/박성우/장연복/강성원
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Abstract
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Postpartum thyroid dysfunction is a syndrome of thyroid dysfunction that occurs in the first year after delivery. Presenting clinically as either painless hypothyroidism or thyrotoxicosis, it usually resolves spontaneously. At the time postpartum
thyroid dysfunction occurs, the relationship between thyroid antibodies and postpartum thyroid dysfunction is even stronger. The close association of these antibodies with postpartum thyroid dysfunction makes the detection of these antibodies an
attractive method for screening large number of pregnant or postpartum women at risk for this disease.
Of the 250 women screened on the second postpartum day, 22 women (8.8%) had positive results for serum antimicrosoma antibody. Among the normal controls, 16% had positive results. 18 of these 22 seropositive patients were followed for at least 6
months
postpartum. 6 patients (2.4%) developed goiter, and 5 patients(2.0%) had biochemical thyroid dysfunction. All 5 patients developed hypothyroidism without thyrotoxic phase. The desease was mild and transient in two patients. But in remaining 3
patients,
goiters and symptoms of hypothyroidism persisted and were treated. The titers of antimicrosomal antibody in women who developed the disease, increased progressively in all patients. There-fore, serum antimicrosomal antibody test after delivery
will
be
useful as a screening test to detect thyroid dysfunction.
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KEYWORD
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